PK Sreemathy is a member of the Central Committee of the CPI(M), and the treasurer of the All India Democratic Women’s Association (AIDWA). Currently a member of parliament from Kannur Lok Sabha constituency, she was elected to the Kerala Legislative Assembly from the Payyannur constituency in 2001 and 2006. PK Sreemathy has served as the Minister for Health & Social Justice in the LDF Ministry led by VS Achuthanandan during 2006-11. She has actively intervened in Parliament on the women's reservation bill and other issues of women. She has participated in 137 debates and asked 497 questions in the 16th Lok Sabha.